Free radicals in ischemic myocardial injury

Free radicals in ischemic myocardial injury.

Myocardial ischemia causes release of chemotactic factors, migration of neutrophils, peroxidation of lipids, and depletion of free radical scavengers. The invading neutrophils may injure the myocardial vasculature and sarcolemma by generating oxygen free radicals. Several agents that affect neutrophils or oxygen radicals were evaluated in a canine model of regional myocardial ischemia and reper...

Free radicals and myocardial injury: pharmacologic implications.

A GROWING NUMBER of articles purport to demonstrate the importance of oxygen free radicals in a variety of pathophysiologic processes, including injury due to radiation, inflammation, and oxygen toxicity. The purpose of this essay is to examine the hypothesis that activated oxygen species may play a role in the extension of myocardial injury due to ischemia followed by reperfusion. Activated ox...

The role of the neutrophil and free radicals in ischemic myocardial injury.

The association of coronary artery thrombosis with the onset of acute myocardial infarction has provided the rationale for the development of pharmacologic and/or physical methods for the restoration of coronary artery blood flow. The institution of pharmacologic methods for myocardial reperfusion has resulted in a reduction in mortality leading to acceptance of thrombolytic therapy as the stan...

Free radicals and tissue injury -

Isoflurane produces delayed preconditioning against spinal cord ischemic injury via release of free radicals in rabbits.

BACKGROUND Whether isoflurane preconditioning produces delayed neuroprotection in the spinal cord is unclear. The authors tested the hypothesis that isoflurane produces delayed preconditioning against spinal cord ischemic injury and, further, that the beneficial effect is dependent on free radicals. METHODS In experiment 1, 63 rabbits were randomly assigned to seven groups (n = 9 each): Anima...